Posts

Viruses - Phage Therapy

In an earlier blog , I mentioned the discovery of bacteriophages (viruses that kill bacteria) and asked why they weren’t used as treatment/prevention for bacterial diseases? Pranay Lal’s Invisible Empire answers that question.   First, says Lal, hierarchy matters. Some top biologists at the time offered alternate explanations – what if, they said, the killer wasn’t a virus but enzymes released by other bacteria? While d’Herelle was outranked, he used bacteriophages to treat a handful of patients suffering from bacterial dysentery. Years later, he cured a few more patients suffering from the bubonic plague. He tried his method in India to treat cholera outbreaks with great success. Sadly, his successes were few and even with the India case, where the effects were on large number of people, the trials had to stop due to the start of the Satyagraha movement (non-cooperation).   The few trials conducted after that didn’t help the case for various reasons: “The small-...

Singapore #2: Marina Bay Sands

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Marina Bay Sands. An iconic landmark of Singapore.   A 5-star resort with a casino. It includes a luxury shopping mall. An ArtScience museum. A huge theatre. A floating Apple store. Celebrity chef and signature restaurants. The hotel part consists of 3 curved towers of 55 floors each. Joining their tops is the Sands Skypark, a 340 meter skyway shaped like a ship. The purpose of this resort? To aid with Singapore’s economic and tourism objectives. The video below gives an all-round view.   As our 14 yo daughter never tires of reminding us, we rarely never splurge on anything. So we decided to spend two days at this iconic hotel (We initially considered a one-day stay, but that would have meant we’d barely have unpacked before it would be time to checkout).   Our room was on the 13 th floor, with a great view of the Gardens by the Bay and its light show. That is a huge urban park with cooled conservatories (lounges for growing delicate plants), a (pay) area with a spe...

Singapore #1: Indoor Skydiving Etc

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This summer, we’d planned to visit Dubai. But repeated attacks on Iran early this year made us reconsider. What if another round of attacks happened during our visit? What if our flight got cancelled at the last minute? What if we got stranded after reaching there?   (This was before all out war began).   So we switched to Singapore as the destination, even though we’d been there before. Even then, we were nervous – what if jet fuel ran out due to the closure of the Straits of Hormuz? Anyways, we went ahead. A benefit in all this? My wife found if we re-did the hotel bookings with the uncertainty of the war and the ceasefire, prices were a lot less! ~~   Singapore immigration was impressive. You place your passport on a scanner, look at the camera and the system compares details and face with the visa application already submitted. That’s it – the turnstile opens and you’re done. No human interaction, no questions from an immigration official about purpose of v...

Viruses - Bacteriophages

One of the chapters in Pranay Lal’s Invisible Empire starts with these lines: “Say the word ‘virus’ and the first thought that comes to the mind is of the diseases they cause.” But they can also be the cure for some diseases, he writes.   The Britisher, Ernest Hankin, was sent to India. His job was to “protect British troops from infectious diseases”. Like cholera. By 1894, he was curious about the Maagh Mela in Allahabad, on the banks of the Ganga. Over 3 million devotees arrived every day during that festival. He inspected the waters during this period: “There was very little bacterial contamination of their waters despite the multitudes of people and their cattle bathing in them, discarding their waste and burning corpses along their banks.” By 1895, he had written a paper that the Ganga was cleaner than most British or European rivers , “despite the way they were treated”. He wondered why that was the case, how the Ganga managed to avoid the decay seen in European ...

Viruses - Hard to Categorize

We think of viruses as being tiny, much tinier than bacteria. But as they say about mutual funds, past performance is not indicative of future results! In 2003, scientists discovered a “giant” virus. A typical virus has around 100 genes, this one had 1262. More giant viruses were found from that point onwards. Pranay Lal points out something startling in Invisible Empire : “Some viruses are so large that they can be parasitized by smaller viruses.” Sounded like Russian dolls.   The discovery of giant viruses reopened the debate on how viruses came to exist. Broadly speaking, there are two schools of theories. The first one says that viruses got started just before or around the same time as life on earth (remember how viruses are said to be on the border of living and non-living? And that viruses need to insert themselves into living cells to kick into action? That is why, in theory at least, they could have gotten started before life got started). The second one says that...

Viruses - the Microscopes Story

In Invisible Empire , Pranay Lal points out that it was the invention of the microscope that finally proved that “infinitesimally tiny organisms” did exist: “The microscope became a weapon for scientific validation.” The inventor of some of the best microscopes of the time, Antoine van Leeuwenhoek, wrote a lot about the different types of microbes he could see. These came to be called bacteria.   As the microscopes kept getting better, the aim turned from curiosity to trying to identify which bacteria caused particular diseases. Man learnt to even isolate and grow bacteria in culture. In 1857, an unknown agricultural disease hit tobacco. Adolf Mayer found that whatever caused the disease could pass through filter paper. But not through double filter paper. He concluded that the microbe in question was a bacteria, but far tinier than anything that could be seen with the best equipment of the times.   In 1885, Martinus Beijernick was investigating a different tobacco...

Learning to use AI

Kids use AI for their schoolwork. Plenty of them use it, not as an assistant, but as the entity that does all the work. That is a problem obviously.   This blog is not on a solution for that problem (None exists. Not yet anyway). Instead, this blog is based on a post by college student Maximilian Milovidov on a course called Writing AI . What’s unique about it? “(It) might be the only one on campus where artificial intelligence was not prohibited but, rather,  required .” The spirit of this course is an interesting experiment: “What if we taught students to use AI critically, rather than insisting they ignore it or assume they're using it to cheat?” AI, after all, he says, is here to stay. You can’t wish it away any more than our ancestors could wish away the printing press.   Here’s how the course works. Students have to bring their own ideas and outlines to the class. “We fed drafts into a chatbot while documenting its suggestions and then explaining...